Pharmacokinetics of ophthalmic corticosteroids.

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pharmacokinetics of ophthalmic corticosteroids.

Corticosteroids have been used by ophthalmologists with increasing frequency over the past 30 years, with the concomitant development of a diverse range of drop, ointment, subconjunctival, and oral preparations. Though the clinical benefits and side effects of such corticosteroid preparations have been well documented, their basic pharmacokinetics in the human eye have yet to be fully establish...

متن کامل

Pharmacokinetics and receptor-mediated pharmacodynamics of corticosteroids.

The corticosteroids, such as prednisolone and methylprednisolone, provide diverse antiinflammatory and immunosuppressive effects which typically show responses with slow onset and prolonged duration. This report summarizes modeling efforts which are successful in describing such steroid effects. Clinical effects with such a pattern, including adrenal suppression and altered trafficking of basop...

متن کامل

Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma.

The pharmacokinetic and pharmacodynamic effects of inhaled corticosteroids (ICS) have shaped the efficacy and safety of these agents in the treatment of asthma. Important pharmacokinetic and pharmacodynamic characteristics that can enhance the efficacy of ICS include small particle size, high glucocorticoid-receptor-binding affinity, long pulmonary residence time and lipid conjugation. These ch...

متن کامل

Ocular Pharmacokinetics of a Novel Loteprednol Etabonate 0.4% Ophthalmic Formulation

INTRODUCTION Topical ophthalmic formulations of corticosteroids are commonly used to treat a variety of ocular diseases and conditions that have an inflammatory component. The purpose of this study was to evaluate the effect of the mucus-penetrating particle (MPP) technology on the pharmacokinetic profile of loteprednol etabonate in the ocular tissues of rabbits. METHODS Forty-eight New Zeala...

متن کامل

Corticosteroids in Infectious Diseases

Accumulated data based on experiences with curtico,teroids in the management uf infectious disea­ses, have proved that they are very dfective and ,afe drugs provided that are administered properly.  The Corticosteroids arc administered mainly be­c,1usc o; antitoxic, antiimflammatory a11d antiallcrgic effects, the cndotoxius are ncuturalized, generalized body reactions are diminished, damaged t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 1992

ISSN: 0007-1161

DOI: 10.1136/bjo.76.11.681